Drake, 36, and Williams, 41, are dating and were even photographed kissing while dining at a fancy restaurant.
“Sidebar, Serena, your husband a groupie,” Drake raps in the song. “He claim we don’t got a problem, but no, boo, it is like you comin’ for sushi. We might pop up on ’em at will like Suzuki.
“For your birthday, your man got a table at Hibachi. Last time I ate there, [Lil] Wayne was doin’ numbers off the cup like Yahtzee and Paris Hilton was steady duckin’ the paparazzi.”
While not mentioning Drake by name, Ohanian took to Twitter to take pride in being his wife’s groupie, who replied to the tweet with four lovable emojies.
“The reason I stay winning is because I’m relentless about being the absolute best at whatever I do – including being the best groupie for my wife & daughter,” Ohanian tweeted.
Did Drake and Serena Williams date?
The rapper has mentioned Williams in his song before, name-dropping her in “Worst Behavior.”
“I swear I could beat Serena when she playin’ with her left,” Drake raps.
Drake was also seen at Wimbledon in 2018 cheering on Williams, when she was already married to Ohanian.
Ohanian is the co-founder of Reddit, but he kept a low profile until marrying Williams in 2017.